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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K5
All Species:
23.33
Human Site:
Y574
Identified Species:
51.33
UniProt:
Q99683
Number Species:
10
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99683
NP_005914.1
1374
154537
Y574
T
K
I
Y
Q
P
S
Y
L
S
I
N
N
E
V
Chimpanzee
Pan troglodytes
XP_001171211
1375
154924
Y575
T
K
I
Y
Q
P
S
Y
L
S
I
N
N
E
V
Rhesus Macaque
Macaca mulatta
XP_001111127
1297
143635
N541
N
K
V
L
L
P
A
N
L
E
V
R
G
T
D
Dog
Lupus familis
XP_533420
1645
181128
Y845
T
K
I
Y
Q
P
S
Y
L
S
I
N
N
E
V
Cat
Felis silvestris
Mouse
Mus musculus
O35099
1380
154441
Y581
T
K
I
Y
Q
P
S
Y
L
S
I
N
N
E
V
Rat
Rattus norvegicus
XP_001073260
1338
150427
Y545
T
K
I
Y
Q
P
S
Y
L
S
I
N
N
E
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511920
1243
141469
M518
H
C
K
K
F
F
E
M
V
N
T
I
T
E
E
Chicken
Gallus gallus
XP_419725
1260
143069
D518
Y
V
L
H
N
S
D
D
F
Q
I
Y
F
C
T
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001155222
1364
153160
Y563
T
K
V
Y
Q
P
S
Y
L
S
I
N
K
D
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477089
1363
155478
S519
A
S
K
I
K
S
V
S
L
Y
K
R
D
D
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001202919
1288
145042
D526
V
S
T
Y
K
R
D
D
R
C
L
F
L
Y
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
44.9
68
N.A.
94.1
92.7
N.A.
84.4
80.4
N.A.
71.7
N.A.
40.6
N.A.
N.A.
44.6
Protein Similarity:
100
99.4
61.3
73.1
N.A.
95.8
94.4
N.A.
87.8
87
N.A.
84.1
N.A.
58.2
N.A.
N.A.
60.7
P-Site Identity:
100
100
20
100
N.A.
100
100
N.A.
6.6
6.6
N.A.
73.3
N.A.
6.6
N.A.
N.A.
13.3
P-Site Similarity:
100
100
40
100
N.A.
100
100
N.A.
20
20
N.A.
86.6
N.A.
26.6
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
0
0
0
10
0
0
0
0
0
0
0
10
% A
% Cys:
0
10
0
0
0
0
0
0
0
10
0
0
0
10
0
% C
% Asp:
0
0
0
0
0
0
19
19
0
0
0
0
10
19
10
% D
% Glu:
0
0
0
0
0
0
10
0
0
10
0
0
0
55
10
% E
% Phe:
0
0
0
0
10
10
0
0
10
0
0
10
10
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% G
% His:
10
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
46
10
0
0
0
0
0
0
64
10
0
0
0
% I
% Lys:
0
64
19
10
19
0
0
0
0
0
10
0
10
0
0
% K
% Leu:
0
0
10
10
10
0
0
0
73
0
10
0
10
0
0
% L
% Met:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% M
% Asn:
10
0
0
0
10
0
0
10
0
10
0
55
46
0
0
% N
% Pro:
0
0
0
0
0
64
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
55
0
0
0
0
10
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
10
0
0
10
0
0
19
0
0
10
% R
% Ser:
0
19
0
0
0
19
55
10
0
55
0
0
0
0
0
% S
% Thr:
55
0
10
0
0
0
0
0
0
0
10
0
10
10
10
% T
% Val:
10
10
19
0
0
0
10
0
10
0
10
0
0
0
55
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
0
64
0
0
0
55
0
10
0
10
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _